DeCS

Descriptor English:

Leucine Zippers

Descriptor Spanish:

Leucina Zippers

Spanish from Spain

Descriptor

cremalleras de leucina

Scope note:

"Motivos de unión a ADN formados por dos alfahélices que se entrelazan durante unos 8 giros en una espiral entrelazada y luego se bifurcan para formar estructuras en forma de Y. Las leucinas que se encuentran en repeticiones heptádicas terminan en los mismos lados de las hélices y son adyacentes unas a otras en el tronco de la Y (la región ""cremallera""). Los residuos de unión al ADN se encuentran en la región bifurcada de la Y."

Descriptor Portuguese:

Zíper de Leucina

Descriptor French:

Glissières à leucine

Entry term(s):

Leucine Zipper
Zipper, Leucine
Zippers, Leucine

Tree number(s):

G02.111.570.820.709.275.500.520

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016350

Scope note:

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

Amino Acid Sequence (1989-1990)
DNA-Binding Proteins (1989-1990)
Molecular Sequence Data (1989-1990)

Public MeSH Note:

History Note:

DeCS ID:

29002

Unique ID:

D016350

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1991/01/01

Date of Entry:

1990/05/29

Revision Date:

2016/05/31

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Amino Acid Motifs [G02.111.570.820.709.275.500]

Amino Acid Motifs

Ankyrin Repeat [G02.111.570.820.709.275.500.030]

Ankyrin Repeat

AT-Hook Motifs [G02.111.570.820.709.275.500.050]

AT-Hook Motifs

Cystine Knot Motifs [G02.111.570.820.709.275.500.127]

Cystine Knot Motifs

F-Box Motifs [G02.111.570.820.709.275.500.205]

F-Box Motifs

Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]

Helix-Loop-Helix Motifs

Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]

Immunoreceptor Tyrosine-Based Activation Motif

Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]

Immunoreceptor Tyrosine-Based Inhibition Motif

Kazal Motifs [G02.111.570.820.709.275.500.490]

Kazal Motifs

Kelch Repeat [G02.111.570.820.709.275.500.500]

Kelch Repeat

Leucine Zippers [G02.111.570.820.709.275.500.520]

Leucine Zippers

Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]

Poly-ADP-Ribose Binding Motif

RNA-Binding Motifs [G02.111.570.820.709.275.500.869]

RNA-Binding Motifs

Sterile Alpha Motif [G02.111.570.820.709.275.500.898]

Sterile Alpha Motif

AAA Domain [G02.111.570.820.709.275.500.913]

AAA Domain

Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]

Tetratricopeptide Repeat

WD40 Repeats [G02.111.570.820.709.275.500.927]

WD40 Repeats

Zinc Fingers [G02.111.570.820.709.275.500.985]

Zinc Fingers

Leucine Zippers - Preferred

Concept UI	M0024992
Scope note	DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
Preferred term	Leucine Zippers
Entry term(s)	Leucine Zipper Zipper, Leucine Zippers, Leucine

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